A SUCCESSFUL GENETIC TARGETING SEQUENCE FOR USE IN PROLIFERATIVE DISEASE THERAPY

Unregulated cellular prolifieration is a pathophysiologic event common to several clinically significant disorders, including cancer, rheumatoid arthritis and psoriasis. Directed transcriptional silencing of a cohort of genes involved in the proliferation pathway represents a potential therapeutic approach for such disorders.

Researchers at UCSF have used the DNA binding domain of a highly conserved DNA-binding factor as a targetting domain in chimeric proteins to specifically block a limited set of genes associated with cell proliferation. They found that they were able to successfully induce apoptosis in several types of tumor cells. Application of these chimeric proteins may provide a useful treatment for proliferative diseases.

If you would like to receive further information about this technology and potential licensing opportunities, please contact:

Joel B. Kirschbaum, Ph.D.
Director & Senior Technology Portfolio Manager
(415) 353-4462 phone
(415) 348-1579 fax
Joel Kirschbaum, Ph.D.

Reference: OTM Case #SF99-095