TRANSCRIPTION FACTOR FOR CONTROL OF CARDIAC GENE EXPRESSION

The transcription factor TEF-1 is a key regulator of gene expression, especially with muscle-specific promoters found in cardiac and skeletal muscle cells. Certain targets of TEF-1 regulation are involved in various cardiovascular disorders, including myocardial hypertrophy, an increase in the mass of the heart. Researchers at UCSF have identified isoforms of TEF-1 that differentially regulate transcriptional activation in cardiac cells. These isoforms of TEF-1 may be useful for manipulating transcription levels of genes responsible for cardiac and skeletal hypertrophy and could result in pharmaceutical formulations or gene therapy techniques to treat or prevent various cardiac diseases through transcriptional regulation.

If you would like to receive further information about this technology and potential licensing opportunities, please contact:

Joel B. Kirschbaum, Ph.D.
Director & Senior Technology Portfolio Manager
(415) 353-4462 phone
(415) 348-1579 fax
Joel Kirschbaum, Ph.D.

Reference: OTM Case #SF97-037