NOVEL DRUG DISCOVERY TARGETS TO IMPROVE HUMAN AGING

C. elegans reproductive system has been shown to regulate lifespan. Genetic or physical ablation of germ cells results in a substantial lifespan extension, but the mechanism by which this effect occurs has remained largely unknown.

Now researchers at UCSF have identified 27 C. elegans genes required for the lifespan extension of germ cell ablated animals, and 2 genes that enhance the lifespan extension. These genes are potentially important targets for the development of therapeutics capable of improving human aging, the diseases of aging, or to extend human lifespan.

Selected Reference:

Hsin, H. & Kenyon. Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399, 362-366 (1999).

If you would like to receive further information about this technology and potential licensing opportunities, please contact:


Michael Karasik
Administrative Manager
(415) 353-4472 phone
(415) 348-1579 fax
michael.karasik@ucsf.edu

Reference: OTM Case #SF2005-004