NOVEL INDICATIONS FOR TRANSFORMING GROWTH FACTOR BETA MODULATING AGENTS (AGONISTS AND ANTAGONISTS) (SF04-004)

Transforming growth factor beta (TGFß) is a multi-functional cytokine that has diverse functions throughout the body and is implicated in playing a role in a broad range of diseases. Using animal models, UCSF researchers have identified a previously unrecognized physiological response regulated by TGFß. Since TGFß’s role in regulating this response has not been commercially exploited thus far, these studies will likely broaden label claims for drugs currently in development that modulate TGFß bioavailability, activity, and action. In addition, the UCSF research team has revealed the underlying pathway regulating TGFß bioavailability in this context, thereby also identifying multiple targets upstream as well as downstream, of TGFß that could be used as therapeutic strategies to alter TGFß effector responses. If the findings in mice are supported by clinical evidence of this novel role of TGFß, the implications of these findings are enormous and could yield new approaches for treating a broad range of human diseases by altering TGFß bioavailability, levels, or interaction with TGFß receptors.

If you would like to receive further information about this technology and potential licensing opportunities, please contact:

Sunita Rajdev, Ph.D.
Licensing Officer
Phone: (415) 353-4470
Fax: (415) 348-1579
Sunita.rajdev@ucsf.edu

Reference: OTM Case #SF04-004